T(FH) Cells Induced by Vaccination and Following SIV Challenge Support Env-Specific Humoral Immunity in the Rectal-Genital Tract and Circulation of Female Rhesus Macaques

T follicular helper (T(FH)) cells are pivotal in lymph node (LN) germinal center (GC) B cell affinity maturation. Circulating CXCR5(+) CD4(+) T (cT(FH)) cells have supported memory B cell activation and broadly neutralizing antibodies in HIV controllers. We investigated the contribution of LN SIV-sp...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Helmold Hait, Sabrina, Hogge, Christopher James, Rahman, Mohammad Arif, Hunegnaw, Ruth, Mushtaq, Zuena, Hoang, Tanya, Robert-Guroff, Marjorie
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7876074/
https://ncbi.nlm.nih.gov/pubmed/33584682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.608003
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