Eliciting the silent lucensomycin biosynthetic pathway in Streptomyces cyanogenus S136 via manipulation of the global regulatory gene adpA

Actinobacteria are among the most prolific sources of medically and agriculturally important compounds, derived from their biosynthetic gene clusters (BGCs) for specialized (secondary) pathways of metabolism. Genomics witnesses that the majority of actinobacterial BGCs are silent, most likely due to...

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Publicado en:Sci Rep
Autores principales: Yushchuk, Oleksandr, Ostash, Iryna, Mösker, Eva, Vlasiuk, Iryna, Deneka, Maksym, Rückert, Christian, Busche, Tobias, Fedorenko, Victor, Kalinowski, Jörn, Süssmuth, Roderich D., Ostash, Bohdan
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875965/
https://ncbi.nlm.nih.gov/pubmed/33568768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-82934-6
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