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Eliciting the silent lucensomycin biosynthetic pathway in Streptomyces cyanogenus S136 via manipulation of the global regulatory gene adpA

Actinobacteria are among the most prolific sources of medically and agriculturally important compounds, derived from their biosynthetic gene clusters (BGCs) for specialized (secondary) pathways of metabolism. Genomics witnesses that the majority of actinobacterial BGCs are silent, most likely due to...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yushchuk, Oleksandr, Ostash, Iryna, Mösker, Eva, Vlasiuk, Iryna, Deneka, Maksym, Rückert, Christian, Busche, Tobias, Fedorenko, Victor, Kalinowski, Jörn, Süssmuth, Roderich D., Ostash, Bohdan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875965/
https://ncbi.nlm.nih.gov/pubmed/33568768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-82934-6
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