Microglial Hyperreactivity Evolved to Immunosuppression in the Hippocampus of a Mouse Model of Accelerated Aging and Alzheimer’s Disease Traits

Neuroinflammation is a risk factor for Alzheimer’s disease (AD). We sought to study the glial derangement in AD using diverse experimental models and human brain tissue. Besides classical pro-inflammatory cytokines, we analyzed chitinase 3 like 1 (CHI3L1 or YKL40) and triggering receptor expressed o...

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Detalles Bibliográficos
Publicado en:Front Aging Neurosci
Main Authors: Molina-Martínez, Patricia, Corpas, Rubén, García-Lara, Elisa, Cosín-Tomás, Marta, Cristòfol, Rosa, Kaliman, Perla, Solà, Carme, Molinuevo, José Luis, Sánchez-Valle, Raquel, Antonell, Anna, Lladó, Albert, Sanfeliu, Coral
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021
Assuntos:
Neuroscience
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875867/
https://ncbi.nlm.nih.gov/pubmed/33584248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2020.622360
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