Application of a plasmin generation assay to define pharmacodynamic effects of tranexamic acid in women undergoing cesarean delivery

BACKGROUND: Tranexamic acid (TXA) is used to reduce bleeding. TXA inhibits plasmin(ogen) binding to fibrin and reduces fibrinolysis. TXA antifibrinolytic activity is typically measured by clot lysis assays; however, effects on plasmin generation (PG) are unclear due to a lack of tools to measure PG...

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Detalhes bibliográficos
Publicado no:J Thromb Haemost
Main Authors: Miszta, Adam, Ahmadzia, Homa K., Luban, Naomi L. C., Li, Shuhui, Guo, Dong, Holle, Lori A., Berger, Jeffrey S., James, Andra H., Gobburu, Jogarao V. S., van den Anker, John, de Laat, Bas, Wolberg, Alisa S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875467/
https://ncbi.nlm.nih.gov/pubmed/33001565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.15114
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