Genome-scale CRISPR screening for modifiers of cellular LDL uptake

Hypercholesterolemia is a causal and modifiable risk factor for atherosclerotic cardiovascular disease. A critical pathway regulating cholesterol homeostasis involves the receptor-mediated endocytosis of low-density lipoproteins into hepatocytes, mediated by the LDL receptor. We applied genome-scale...

Full description

Saved in:
Bibliographic Details
Published in:PLoS Genet
Main Authors: Emmer, Brian T., Sherman, Emily J., Lascuna, Paul J., Graham, Sarah E., Willer, Cristen J., Ginsburg, David
Format: Artigo
Language:Inglês
Published: Public Library of Science 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875399/
https://ncbi.nlm.nih.gov/pubmed/33513160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009285
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items