T-bet-dependent ILC1- and NK cell-derived IFN-γ mediates cDC1-dependent host resistance against Toxoplasma gondii

Host resistance against intracellular pathogens requires a rapid IFN-γ mediated immune response. We reveal that T-bet-dependent production of IFN-γ is essential for the maintenance of inflammatory DCs at the site of infection with a common protozoan parasite, Toxoplasma gondii. A detailed analysis o...

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Publicado en:PLoS Pathog
Autores principales: López-Yglesias, Américo H., Burger, Elise, Camanzo, Ellie, Martin, Andrew T., Araujo, Alessandra M., Kwok, Samantha F., Yarovinsky, Felix
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2021
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875365/
https://ncbi.nlm.nih.gov/pubmed/33465134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008299
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