Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans

The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy subjects and malaria-exposed individuals. This reveals two B cell lineages: a classical lineage of activated and resting m...

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Publié dans:Cell Rep
Auteurs principaux: Sutton, Henry J., Aye, Racheal, Idris, Azza H., Vistein, Rachel, Nduati, Eunice, Kai, Oscar, Mwacharo, Jedida, Li, Xi, Gao, Xin, Andrews, T. Daniel, Koutsakos, Marios, Nguyen, Thi H.O., Nekrasov, Maxim, Milburn, Peter, Eltahla, Auda, Berry, Andrea A., KC, Natasha, Chakravarty, Sumana, Sim, B. Kim Lee, Wheatley, Adam K., Kent, Stephen J., Hoffman, Stephen L., Lyke, Kirsten E., Bejon, Philip, Luciani, Fabio, Kedzierska, Katherine, Seder, Robert A., Ndungu, Francis M., Cockburn, Ian A.
Format: Artigo
Langue:Inglês
Publié: Cell Press 2021
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7873835/
https://ncbi.nlm.nih.gov/pubmed/33567273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108684
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