Inactivation of N-Acetylglucosaminyltransferase I and α1,3-Fucosyltransferase Genes in Nicotiana tabacum BY-2 Cells Results in Glycoproteins With Highly Homogeneous, High-Mannose N-Glycans

Nicotiana tabacum Bright Yellow-2 (BY-2) suspension cells are among the most commonly used plant cell lines for producing biopharmaceutical glycoproteins. Recombinant glycoproteins are usually produced with a mix of high-mannose and complex N-glycans. However, N-glycan heterogeneity is a concern for...

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Publicat a:Front Plant Sci
Autors principals: Herman, Xavier, Far, Johann, Courtoy, Adeline, Bouhon, Laurent, Quinton, Loïc, De Pauw, Edwin, Chaumont, François, Navarre, Catherine
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Plant Science
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7873608/
https://ncbi.nlm.nih.gov/pubmed/33584780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fpls.2021.634023
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