DNA damage repair as a target in pancreatic cancer: state-of-the-art and future perspectives

Complex rearrangement patterns and mitotic errors are hallmarks of most pancreatic ductal adenocarcinomas (PDAC), a disease with dismal prognosis despite some therapeutic advances in recent years. DNA double-strand breaks (DSB) bear the greatest risk of provoking genomic instability, and DNA damage...

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Bibliografiske detaljer
Udgivet i:Gut
Main Authors: Perkhofer, Lukas, Gout, Johann, Roger, Elodie, Kude de Almeida, Fernando, Baptista Simões, Carolina, Wiesmüller, Lisa, Seufferlein, Thomas, Kleger, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2021
Fag:
Recent Advances in Clinical Practice
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7873425/
https://ncbi.nlm.nih.gov/pubmed/32855305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2019-319984
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