Tumor Frameshift Mutation Proportion Predicts Response to Immunotherapy in Mismatch Repair‐Deficient Prostate Cancer

BACKGROUND: Genomic biomarkers that predict response to anti‐PD1 therapy in prostate cancer are needed. Frameshift mutations are predicted to generate more neoantigens than missense mutations; therefore, we hypothesized that the number or proportion of tumor frameshift mutations would correlate with...

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Detaylı Bibliyografya
Yayımlandı:Oncologist
Asıl Yazarlar: Sena, Laura A., Fountain, Julia, Isaacsson Velho, Pedro, Lim, Su Jin, Wang, Hao, Nizialek, Emily, Rathi, Nityam, Nussenzveig, Roberto, Maughan, Benjamin L., Velez, Miguel Gonzalez, Ashkar, Ryan, Larson, Amanda C., Pritchard, Colin C., Adra, Nabil, Bryce, Alan H., Agarwal, Neeraj, Pardoll, Drew M., Eshleman, James R., Lotan, Tamara L., Antonarakis, Emmanuel S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley & Sons, Inc. 2020
Konular:
Genitourinary Cancer
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7873327/
https://ncbi.nlm.nih.gov/pubmed/33215787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/onco.13601
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