Tumor Frameshift Mutation Proportion Predicts Response to Immunotherapy in Mismatch Repair‐Deficient Prostate Cancer

BACKGROUND: Genomic biomarkers that predict response to anti‐PD1 therapy in prostate cancer are needed. Frameshift mutations are predicted to generate more neoantigens than missense mutations; therefore, we hypothesized that the number or proportion of tumor frameshift mutations would correlate with...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncologist
Main Authors: Sena, Laura A., Fountain, Julia, Isaacsson Velho, Pedro, Lim, Su Jin, Wang, Hao, Nizialek, Emily, Rathi, Nityam, Nussenzveig, Roberto, Maughan, Benjamin L., Velez, Miguel Gonzalez, Ashkar, Ryan, Larson, Amanda C., Pritchard, Colin C., Adra, Nabil, Bryce, Alan H., Agarwal, Neeraj, Pardoll, Drew M., Eshleman, James R., Lotan, Tamara L., Antonarakis, Emmanuel S.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley & Sons, Inc. 2020
Teme:
Genitourinary Cancer
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7873327/
https://ncbi.nlm.nih.gov/pubmed/33215787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/onco.13601
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki