The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes

Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers 1- and 3-methylhistidine (1MH and 3MH), was first reported five decades ago, but remains largely unexplored. Here we report that METTL9 is a...

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Publicado no:Nat Commun
Main Authors: Davydova, Erna, Shimazu, Tadahiro, Schuhmacher, Maren Kirstin, Jakobsson, Magnus E., Willemen, Hanneke L. D. M., Liu, Tongri, Moen, Anders, Ho, Angela Y. Y., Małecki, Jędrzej, Schroer, Lisa, Pinto, Rita, Suzuki, Takehiro, Grønsberg, Ida A., Sohtome, Yoshihiro, Akakabe, Mai, Weirich, Sara, Kikuchi, Masaki, Olsen, Jesper V., Dohmae, Naoshi, Umehara, Takashi, Sodeoka, Mikiko, Siino, Valentina, McDonough, Michael A., Eijkelkamp, Niels, Schofield, Christopher J., Jeltsch, Albert, Shinkai, Yoichi, Falnes, Pål Ø.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7873184/
https://ncbi.nlm.nih.gov/pubmed/33563959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20670-7
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