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Differential Roles of Extracellular Histidine Residues of GPR68 for Proton-Sensing and Allosteric Modulation by Divalent Metal Ions

GPR68, an orphan G-protein coupled receptor, senses protons, couples to multiple G-proteins, and is also activated or inhibited by divalent metal ions. It has seven extracellular histidine residues, although it is not clear how these histidine residues play a role in both proton-sensing and metal io...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Huang, Xi-Ping, Kenakin, Terrence P., Gu, Shuo, Shoichet, Brian K., Roth, Bryan L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7872588/
https://ncbi.nlm.nih.gov/pubmed/32865988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00576
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