Conserved interferon-γ signaling drives clinical response to immune checkpoint blockade therapy in melanoma

SUMMARY: We analyze the transcriptome of baseline and on-therapy tumor biopsies from 101 patients with advanced melanoma treated with nivolumab (anti-PD-1) alone or combined with ipilimumab (anti-CTLA-4). We find that T cell infiltration and interferon-γ (IFNγ) signaling signatures correspond most h...

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Publicado no:Cancer Cell
Main Authors: Grasso, Catherine S., Tsoi, Jennifer, Onyshchenko, Mykola, Abril-Rodriguez, Gabriel, Ross-Macdonald, Petra, Wind-Rotolo, Megan, Champhekar, Ameya, Medina, Egmidio, Torrejon, Davis Y., Shin, Daniel Sanghoon, Tran, Phuong, Kim, Yeon Joo, Puig-Saus, Cristina, Campbell, Katie, Vega-Crespo, Agustin, Quist, Michael, Martignier, Christophe, Luke, Jason J., Wolchok, Jedd D., Johnson, Douglas B., Chmielowski, Bartosz, Hodi, F. Stephen, Bhatia, Shailender, Sharfman, William, Urba, Walter J., Slingluff, Craig L, Diab, Adi, Haanen, John B.A.G., Algarra, Salvador Martin, Pardoll, Drew M., Anagnostou, Valsamo, Topalian, Suzanne L., Velculescu, Victor E., Speiser, Daniel E., Kalbasi, Anusha, Ribas, Antoni
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7872287/
https://ncbi.nlm.nih.gov/pubmed/32916126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.08.005
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