GSK2593074A blocks progression of existing abdominal aortic dilation

OBJECTIVE: Receptor interacting proteins kinase 1 and 3 (RIPK1 and RIPK3) have been shown to play essential roles in the pathogenesis of abdominal aortic aneurysms (AAAs) by mediating necroptosis and inflammation. We previously discovered a small molecular inhibitor GSK2593074A (GSK’074) that binds...

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Detalhes bibliográficos
Publicado no:JVS Vasc Sci
Main Authors: Khoury, Mitri K., Zhou, Ting, Yang, Huan, Prince, Samantha R., Gupta, Kartik, Stranz, Amelia R., Wang, Qiwei, Liu, Bo
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Basic Reserch Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7872141/
https://ncbi.nlm.nih.gov/pubmed/33569546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jvssci.2020.07.001
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