Scalable generalized linear mixed model for region-based association tests in large biobanks and cohorts

With very large sample sizes, biobanks provide an exciting opportunity to identify genetic components of complex traits. To analyze rare variants, region-based multiple variant aggregate tests are commonly used to increase power for association tests. However, due to the substantial computation cost...

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Udgivet i:Nat Genet
Main Authors: Zhou, Wei, Zhao, Zhangchen, Nielsen, Jonas B., Fritsche, Lars G., LeFaive, Jonathon, Taliun, Sarah A. Gagliano, Bi, Wenjian, Gabrielsen, Maiken E., Daly, Mark J., Neale, Benjamin M., Hveem, Kristian, Abecasis, Goncalo R., Willer, Cristen J., Lee, Seunggeun
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7871731/
https://ncbi.nlm.nih.gov/pubmed/32424355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0621-6
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