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Comprehensive quantification of fuel use by the failing and nonfailing human heart

The heart consumes circulating nutrients to fuel lifelong contraction, but a comprehensive mapping of human cardiac fuel use is lacking. We used metabolomics on blood from artery, coronary sinus, and femoral vein in 110 patients with or without heart failure to quantify the uptake and release of 277...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Murashige, Danielle, Jang, Cholsoon, Neinast, Michael, Edwards, Jonathan J., Cowan, Alexis, Hyman, Matthew C., Rabinowitz, Joshua D., Frankel, David S., Arany, Zolt
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7871704/
https://ncbi.nlm.nih.gov/pubmed/33060364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abc8861
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