GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation

Nucleation of microtubules (MTs) is essential for cellular activities, but its mechanism is unknown because of the difficulty involved in capturing rare stochastic events in the early stage of polymerization. Here, combining rapid flush negative stain electron microscopy (EM) and kinetic analysis, w...

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Bibliografiske detaljer
Udgivet i:J Cell Biol
Main Authors: Ayukawa, Rie, Iwata, Seigo, Imai, Hiroshi, Kamimura, Shinji, Hayashi, Masahito, Ngo, Kien Xuan, Minoura, Itsushi, Uchimura, Seiichi, Makino, Tsukasa, Shirouzu, Mikako, Shigematsu, Hideki, Sekimoto, Ken, Gigant, Benoît, Muto, Etsuko
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7871348/
https://ncbi.nlm.nih.gov/pubmed/33544140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202007033
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