GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation

Nucleation of microtubules (MTs) is essential for cellular activities, but its mechanism is unknown because of the difficulty involved in capturing rare stochastic events in the early stage of polymerization. Here, combining rapid flush negative stain electron microscopy (EM) and kinetic analysis, w...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Ayukawa, Rie, Iwata, Seigo, Imai, Hiroshi, Kamimura, Shinji, Hayashi, Masahito, Ngo, Kien Xuan, Minoura, Itsushi, Uchimura, Seiichi, Makino, Tsukasa, Shirouzu, Mikako, Shigematsu, Hideki, Sekimoto, Ken, Gigant, Benoît, Muto, Etsuko
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7871348/
https://ncbi.nlm.nih.gov/pubmed/33544140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202007033
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