GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation

Nucleation of microtubules (MTs) is essential for cellular activities, but its mechanism is unknown because of the difficulty involved in capturing rare stochastic events in the early stage of polymerization. Here, combining rapid flush negative stain electron microscopy (EM) and kinetic analysis, w...

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Dades bibliogràfiques
Publicat a:J Cell Biol
Autors principals: Ayukawa, Rie, Iwata, Seigo, Imai, Hiroshi, Kamimura, Shinji, Hayashi, Masahito, Ngo, Kien Xuan, Minoura, Itsushi, Uchimura, Seiichi, Makino, Tsukasa, Shirouzu, Mikako, Shigematsu, Hideki, Sekimoto, Ken, Gigant, Benoît, Muto, Etsuko
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7871348/
https://ncbi.nlm.nih.gov/pubmed/33544140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202007033
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