Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3/GSDME in triple-negative breast cancer cells

Although tetraarsenic hexoxide is known to exert an anti-tumor effect by inducing apoptosis in various cancer cells, its effect on other forms of regulated cell death remains unclear. Here, we show that tetraarsenic hexoxide induces the pyroptotic cell death through activation of mitochondrial react...

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Publicado no:Cell Death Dis
Main Authors: An, Haein, Heo, Jin Sun, Kim, Pyunggang, Lian, Zenglin, Lee, Siyoung, Park, Jinah, Hong, Eunji, Pang, Kyoungwha, Park, Yuna, Ooshima, Akira, Lee, Jihee, Son, Minjung, Park, Hyeyeon, Wu, Zhaoyan, Park, Kyung-Soon, Kim, Seong-Jin, Bae, Illju, Yang, Kyung-Min
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7870965/
https://ncbi.nlm.nih.gov/pubmed/33558527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03454-9
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