Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3/GSDME in triple-negative breast cancer cells

Although tetraarsenic hexoxide is known to exert an anti-tumor effect by inducing apoptosis in various cancer cells, its effect on other forms of regulated cell death remains unclear. Here, we show that tetraarsenic hexoxide induces the pyroptotic cell death through activation of mitochondrial react...

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Pubblicato in:Cell Death Dis
Autori principali: An, Haein, Heo, Jin Sun, Kim, Pyunggang, Lian, Zenglin, Lee, Siyoung, Park, Jinah, Hong, Eunji, Pang, Kyoungwha, Park, Yuna, Ooshima, Akira, Lee, Jihee, Son, Minjung, Park, Hyeyeon, Wu, Zhaoyan, Park, Kyung-Soon, Kim, Seong-Jin, Bae, Illju, Yang, Kyung-Min
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7870965/
https://ncbi.nlm.nih.gov/pubmed/33558527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03454-9
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