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Inference of phenotype-relevant transcriptional regulatory networks elucidates cancer type-specific regulatory mechanisms in a pan-cancer study

Reconstruction of transcriptional regulatory networks (TRNs) is a powerful approach to unravel the gene expression programs involved in healthy and disease states of a cell. However, these networks are usually reconstructed independent of the phenotypic (or clinical) properties of the samples. There...

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Pubblicato in:NPJ Syst Biol Appl
Autori principali: Emad, Amin, Sinha, Saurabh
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7870953/
https://ncbi.nlm.nih.gov/pubmed/33558504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41540-021-00169-7
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