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Cryo-EM reveals structural breaks in a patient-derived amyloid fibril from systemic AL amyloidosis
Systemic AL amyloidosis is a debilitating and potentially fatal disease that arises from the misfolding and fibrillation of immunoglobulin light chains (LCs). The disease is patient-specific with essentially each patient possessing a unique LC sequence. In this study, we present two ex vivo fibril s...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7870857/ https://ncbi.nlm.nih.gov/pubmed/33558536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21126-2 |
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