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Novel TLR 7/8 agonists for improving NK cell mediated antibody-dependent cellular cytotoxicity (ADCC)

There is a significant interest in designing therapeutic agents that can enhance ADCC and thereby improve clinical responses with approved antibodies. We recently reported the combination of an imidazoquinoline-based TLR7/8 agonist (522) with a monoclonal antibody improved ADCC in vitro and in vivo....

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Khanna, Vidhi, Kim, Hyunjoon, Zhang, Wenqiu, Larson, Peter, Shah, Manan, Griffith, Thomas S., Ferguson, David, Panyam, Jayanth
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7870826/
https://ncbi.nlm.nih.gov/pubmed/33558639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83005-6
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