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The GSK3β-β-catenin-TCF1 pathway improves naive T cell activation in old adults by upregulating miR-181a

MicroRNAs play an important role in the regulation of T cell development, activation, and differentiation. One of the most abundant microRNAs in lymphocytes is miR-181a, which controls T cell receptor (TCR) activation thresholds in thymic selection as well as in peripheral T cell responses. We previ...

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Detalles Bibliográficos
Publicado en:NPJ Aging Mech Dis
Autores principales: Ye, Zhongde, Gould, Timothy M., Zhang, Huimin, Jin, Jun, Weyand, Cornelia M., Goronzy, Jörg J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2021
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7870817/
https://ncbi.nlm.nih.gov/pubmed/33558531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41514-021-00056-9
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