SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity

The causative agent of the COVID-19 pandemic, SARS-CoV-2, is steadily mutating during continuous transmission among humans. Such mutations can occur in the spike (S) protein that binds to the ACE2 receptor and is cleaved by TMPRSS2. However, whether S mutations affect SARS-CoV-2 cell entry remains u...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Ozono, Seiya, Zhang, Yanzhao, Ode, Hirotaka, Sano, Kaori, Tan, Toong Seng, Imai, Kazuo, Miyoshi, Kazuyasu, Kishigami, Satoshi, Ueno, Takamasa, Iwatani, Yasumasa, Suzuki, Tadaki, Tokunaga, Kenzo
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7870668/
https://ncbi.nlm.nih.gov/pubmed/33558493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21118-2
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