Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors

Inhibition of complex I of the mitochondrial respiratory chain (cI) by rotenone and methyl-phenylpyridinium (MPP +) leads to the degeneration of dopaminergic neurons in man and rodents. To formally describe this mechanism of toxicity, an adverse outcome pathway (AOP:3) has been developed that implie...

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Veröffentlicht in:Arch Toxicol
Hauptverfasser: Delp, Johannes, Cediel-Ulloa, Andrea, Suciu, Ilinca, Kranaster, Petra, van Vugt-Lussenburg, Barbara MA, Munic Kos, Vesna, van der Stel, Wanda, Carta, Giada, Bennekou, Susanne Hougaard, Jennings, Paul, van de Water, Bob, Forsby, Anna, Leist, Marcel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2021
Schlagworte:
In Vitro Systems
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7870626/
https://ncbi.nlm.nih.gov/pubmed/33512557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-020-02970-5
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