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Inclusion of variants discovered from diverse populations improves polygenic risk score transferability
The majority of polygenic risk scores (PRSs) have been developed and optimized in individuals of European ancestry and may have limited generalizability across other ancestral populations. Understanding aspects of PRSs that contribute to this issue and determining solutions is complicated by disease...
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| Publicado no: | HGG Adv |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7869832/ https://ncbi.nlm.nih.gov/pubmed/33564748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xhgg.2020.100017 |
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