Methionyl-tRNA synthetase inhibitor has potent in vivo activity in a novel Giardia lamblia luciferase murine infection model

BACKGROUND: Methionyl-tRNA synthetase (MetRS) inhibitors are under investigation for the treatment of intestinal infections caused by Giardia lamblia. OBJECTIVES: To properly analyse the therapeutic potential of the MetRS inhibitor 1717, experimental tools including a robust cell-based assay and a m...

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Dettagli Bibliografici
Pubblicato in:J Antimicrob Chemother
Autori principali: Michaels, Samantha A, Shih, Han-Wei, Zhang, Bailin, Navaluna, Edelmar D, Zhang, Zhongsheng, Ranade, Ranae M, Gillespie, J Robert, Merritt, Ethan A, Fan, Erkang, Buckner, Frederick S, Paredez, Alexander R, Ojo, Kayode K
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7869794/
https://ncbi.nlm.nih.gov/pubmed/32011682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkz567
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