Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFNγ Signaling in Celiac Disease

Celiac disease (CeD) is a complex T cell-mediated enteropathy induced by gluten. Although genome-wide association studies have identified numerous genomic regions associated with CeD, it is difficult to accurately pinpoint which genes in these loci are most likely to cause CeD. We used four differen...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: van der Graaf, Adriaan, Zorro, Maria M., Claringbould, Annique, Võsa, Urmo, Aguirre-Gamboa, Raúl, Li, Chan, Mooiweer, Joram, Ricaño-Ponce, Isis, Borek, Zuzanna, Koning, Frits, Kooy-Winkelaar, Yvonne, Sollid, Ludvig M., Qiao, Shuo-Wang, Kumar, Vinod, Li, Yang, Franke, Lude, Withoff, Sebo, Wijmenga, Cisca, Sanna, Serena, Jonkers, Iris
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7868554/
https://ncbi.nlm.nih.gov/pubmed/33569077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.562434
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