Assessment and visualization of phenome-wide causal relationships using genetic data: an application to dental caries and periodontitis

Hypothesis-free Mendelian randomization studies provide a way to assess the causal relevance of a trait across the human phenome but can be limited by statistical power, sample overlap or complicated by horizontal pleiotropy. The recently described latent causal variable (LCV) approach provides an a...

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Bibliographic Details
Published in:Eur J Hum Genet
Main Authors: Haworth, Simon, Kho, Pik Fang, Holgerson, Pernilla Lif, Hwang, Liang-Dar, Timpson, Nicholas J., Rentería, Miguel E., Johansson, Ingegerd, Cuellar-Partida, Gabriel
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7868372/
https://ncbi.nlm.nih.gov/pubmed/33011735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41431-020-00734-4
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