TPMT Genetic Variability and Its Association with Hematotoxicity in Indonesian Children with Acute Lymphoblastic Leukemia in Maintenance Therapy

PURPOSE: Hematotoxicity monitoring in children with acute lymphoblastic leukemia (ALL) is critical to preventing life-threatening infections and drug discontinuation. The primary drug that causes hematotoxicity in ALL children is 6-mercaptopurine (6-MP). Genetic variability of the drug-metabolizing...

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Bibliographic Details
Published in:Pharmgenomics Pers Med
Main Authors: Rosdiana, Dewi Selvina, Setiabudy, Rianto, Andalusia, Rizka, Gatot, Djajadiman, Louisa, Melva, Bardosono, Saptawati, Instiaty, Instiaty
Format: Artigo
Language:Inglês
Published: Dove 2021
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7868246/
https://ncbi.nlm.nih.gov/pubmed/33568932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/PGPM.S288988
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