Semisynthesis of the Organoarsenical Antibiotic Arsinothricin

Arsinothricin [AST (1)], a new broad-spectrum organoarsenical antibiotic, is a nonproteinogenic analogue of glutamate that effectively inhibits glutamine synthetase. We report the chemical synthesis of an intermediate in the pathway to 1, hydroxyarsinothricin [AST-OH (2)], which can be converted to...

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Bibliografiske detaljer
Udgivet i:J Nat Prod
Main Authors: Suzol, Sazzad H., Howlader, A. Hasan, Galván, Adriana E., Radhakrishnan, Manohar, Wnuk, Stanislaw F., Rosen, Barry P., Yoshinaga, Masafumi
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7867689/
https://ncbi.nlm.nih.gov/pubmed/32830503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jnatprod.0c00522
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