Tractor uses local ancestry to enable inclusion of admixed individuals into GWAS and boost power

Admixed populations are routinely excluded from genomic studies due to concerns over population structure. Here, we present a statistical framework and software package, Tractor, to facilitate inclusion of admixed individuals in association studies by leveraging local ancestry. We test Tractor with...

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Detaylı Bibliyografya
Yayımlandı:Nat Genet
Asıl Yazarlar: Atkinson, Elizabeth G., Maihofer, Adam X., Kanai, Masahiro, Martin, Alicia R., Karczewski, Konrad J., Santoro, Marcos L., Ulirsch, Jacob C., Kamatani, Yoichiro, Okada, Yukinori, Finucane, Hilary K., Koenen, Karestan C., Nievergelt, Caroline M., Daly, Mark J., Neale, Benjamin M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7867648/
https://ncbi.nlm.nih.gov/pubmed/33462486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00766-y
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