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Ribosome-quality control antagonizes the activation of the integrated-stress response on colliding ribosomes
Stalling during translation triggers ribosome quality control (RQC) to maintain proteostasis. Recently, stalling has also been linked to the activation of integrated-stress response (ISR) by Gcn2. How the two processes are coordinated is unclear. Here we show that activation of RQC by Hel2 suppresse...
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| Publicado no: | Mol Cell |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7867595/ https://ncbi.nlm.nih.gov/pubmed/33338396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.11.033 |
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