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Design and Synthesis of Novel Imidazole Derivatives Possessing Triazole Pharmacophore with Potent Anticancer Activity, and In Silico ADMET with GSK-3β Molecular Docking Investigations

A library of novel imidazole-1,2,3-triazole hybrids were designed and synthesized based on the hybrid pharmacophore approach. Therefore, copper(I)catalyzed click reaction of thiopropargylated-imidazole 2 with several organoazides yielded two sets of imidazole-1,2,3-triazole hybrids carrying differen...

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Bibliografske podrobnosti
izdano v:Int J Mol Sci
Main Authors: Al-blewi, Fawzia, Shaikh, Salma Akram, Naqvi, Arshi, Aljohani, Faizah, Aouad, Mohamed Reda, Ihmaid, Saleh, Rezki, Nadjet
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7866082/
https://ncbi.nlm.nih.gov/pubmed/33503871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22031162
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