Dual and Opposite Costimulatory Targeting with a Novel Human Fusion Recombinant Protein Effectively Prevents Renal Warm Ischemia Reperfusion Injury and Allograft Rejection in Murine Models

Many studies have shown both the CD28—D80/86 costimulatory pathway and the PD-1—PD-L1/L2 coinhibitory pathway to be important signals in modulating or decreasing the inflammatory profile in ischemia-reperfusion injury (IRI) or in a solid organ transplant setting. The importance of these two opposing...

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Publicado en:Int J Mol Sci
Autores principales: Guiteras, Jordi, De Ramon, Laura, Crespo, Elena, Bolaños, Nuria, Barcelo-Batllori, Silvia, Martinez-Valenzuela, Laura, Fontova, Pere, Jarque, Marta, Torija, Alba, Bestard, Oriol, Resina, David, Grinyó, Josep M, Torras, Joan
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7865252/
https://ncbi.nlm.nih.gov/pubmed/33530581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22031216
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