Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin

Beclin 1, an autophagy and haploinsufficient tumor-suppressor protein, is frequently monoallelically deleted in breast and ovarian cancers. However, the precise mechanisms by which Beclin 1 inhibits tumor growth remain largely unknown. To address this question, we performed a genome-wide CRISPR/Cas9...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Wijshake, Tobias, Zou, Zhongju, Chen, Beibei, Zhong, Lin, Xiao, Guanghua, Xie, Yang, Doench, John G., Bennett, Lynda, Levine, Beth
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2021
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7865132/
https://ncbi.nlm.nih.gov/pubmed/33495338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020478118
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