Sperm DNA methylation mediates the association of male age on reproductive outcomes among couples undergoing infertility treatment

Parental age at time of offspring conception is increasing in developed countries. Advanced male age is associated with decreased reproductive success and increased risk of adverse neurodevelopmental outcomes in offspring. Mechanisms for these male age effects remain unclear, but changes in sperm DN...

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Vydáno v:Sci Rep
Hlavní autoři: Oluwayiose, Oladele A., Wu, Haotian, Saddiki, Hachem, Whitcomb, Brian W., Balzer, Laura B., Brandon, Nicole, Suvorov, Alexander, Tayyab, Rahil, Sites, Cynthia K., Hill, Lisa, Marcho, Chelsea, Pilsner, J. Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864951/
https://ncbi.nlm.nih.gov/pubmed/33547328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80857-2
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