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Genetic and Environmental Factors Influence the Pleomorphy of LRRK2 Parkinsonism

Missense mutations in the LRRK2 gene were first identified as a pathogenic cause of Parkinson’s disease (PD) in 2004. Soon thereafter, a founder mutation in LRRK2, p.G2019S (rs34637584), was described, and it is now estimated that there are approximately 100,000 people worldwide carrying this risk v...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Chittoor-Vinod, Vinita G., Nichols, R. Jeremy, Schüle, Birgitt
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864502/
https://ncbi.nlm.nih.gov/pubmed/33494262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22031045
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