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IP(3)-mediated Ca(2+) release regulates atrial Ca(2+) transients and pacemaker function by stimulation of adenylyl cyclases

Inositol trisphosphate (IP(3)) is a Ca(2+)-mobilizing second messenger shown to modulate atrial muscle contraction and is thought to contribute to atrial fibrillation. Cellular pathways underlying IP(3) actions in cardiac tissue remain poorly understood, and the work presented here addresses the que...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Capel, Rebecca A., Bose, Samuel J., Collins, Thomas P., Rajasundaram, Skanda, Ayagama, Thamali, Zaccolo, Manuela, Burton, Rebecca-Ann Beatrice, Terrar, Derek A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864251/
https://ncbi.nlm.nih.gov/pubmed/33064562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00380.2020
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