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Secretory galectin-3 induced by glucocorticoid stress triggers stemness exhaustion of hepatic progenitor cells

Adult progenitor cell populations typically exist in a quiescent state within a controlled niche environment. However, various stresses or forms of damage can disrupt this state, which often leads to dysfunction and aging. We built a glucocorticoid (GC)-induced liver damage model of mice, found that...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yang, Fan, Zhang, Fan, Ji, Xueying, Jiang, Xin, Xue, Mengjuan, Yu, Huiyuan, Hu, Xiaona, Bao, Zhijun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864077/
https://ncbi.nlm.nih.gov/pubmed/32989051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012974
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