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M8R tropomyosin mutation disrupts actin binding and filament regulation: The beginning affects the middle and end
Dilated cardiomyopathy (DCM) is associated with mutations in cardiomyocyte sarcomeric proteins, including α-tropomyosin. In conjunction with troponin, tropomyosin shifts to regulate actomyosin interactions. Tropomyosin molecules overlap via tropomyosin–tropomyosin head-to-tail associations, forming...
Gardado en:
| Publicado en: | J Biol Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7863880/ https://ncbi.nlm.nih.gov/pubmed/33020181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014713 |
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