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M8R tropomyosin mutation disrupts actin binding and filament regulation: The beginning affects the middle and end

Dilated cardiomyopathy (DCM) is associated with mutations in cardiomyocyte sarcomeric proteins, including α-tropomyosin. In conjunction with troponin, tropomyosin shifts to regulate actomyosin interactions. Tropomyosin molecules overlap via tropomyosin–tropomyosin head-to-tail associations, forming...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Racca, Alice Ward, Rynkiewicz, Michael J., LaFave, Nicholas, Ghosh, Anita, Lehman, William, Moore, Jeffrey R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863880/
https://ncbi.nlm.nih.gov/pubmed/33020181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014713
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