Characterizing human α-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases

Mammalian Asn-linked glycans are extensively processed as they transit the secretory pathway to generate diverse glycans on cell surface and secreted glycoproteins. Additional modification of the glycan core by α-1,6-fucose addition to the innermost GlcNAc residue (core fucosylation) is catalyzed by...

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Udgivet i:J Biol Chem
Main Authors: Boruah, Bhargavi M., Kadirvelraj, Renuka, Liu, Lin, Ramiah, Annapoorani, Li, Chao, Zong, Guanghui, Bosman, Gerlof P., Yang, Jeong-Yeh, Wang, Lai-Xi, Boons, Geert-Jan, Wood, Zachary A., Moremen, Kelley W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Glycobiology and Extracellular Matrices
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863877/
https://ncbi.nlm.nih.gov/pubmed/33004438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014625
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