Human N-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite

Asn-linked oligosaccharides are extensively modified during transit through the secretory pathway, first by trimming of the nascent glycan chains and subsequently by initiating and extending multiple oligosaccharide branches from the trimannosyl glycan core. Trimming and branching pathway steps are...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Kadirvelraj, Renuka, Yang, Jeong-Yeh, Sanders, Justin H., Liu, Lin, Ramiah, Annapoorani, Prabhakar, Pradeep Kumar, Boons, Geert-Jan, Wood, Zachary A., Moremen, Kelley W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5939069/
https://ncbi.nlm.nih.gov/pubmed/29666272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716988115
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