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Reduced rDNA transcription diminishes skeletal muscle ribosomal capacity and protein synthesis in cancer cachexia

Muscle wasting in cancer is associated with deficits in protein synthesis, yet the mechanisms underlying this anabolic impairment remain poorly understood. The capacity for protein synthesis is mainly determined by the abundance of muscle ribosomes, which is in turn regulated by transcription of the...

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Publicado en:FASEB J
Autores principales: Kim, Hyo-Gun, Huot, Joshua R., Pin, Fabrizio, Guo, Bin, Bonetto, Andrea, Nader, Gustavo A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2021
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863588/
https://ncbi.nlm.nih.gov/pubmed/33527503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.202002257R
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