Overexpression of SP1 restores autophagy to alleviate acute renal injury induced by ischemia-reperfusion through the miR-205/PTEN/Akt pathway

BACKGROUND: Acute kidney injury (AKI) is a major kidney disease with poor clinical outcome. SP1, a well-known transcription factor, plays a critical role in AKI and subsequent kidney repair through the regulation of various cell biologic processes. However, the underlying mechanism of SP1 in these p...

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Bibliographic Details
Published in:J Inflamm (Lond)
Main Authors: Huang, Chong, Chen, Yan, Lai, Bin, Chen, Yan-Xia, Xu, Cheng-Yun, Liu, Yuan-Fei
Format: Artigo
Language:Inglês
Published: BioMed Central 2021
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863508/
https://ncbi.nlm.nih.gov/pubmed/33546692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12950-021-00270-y
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