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Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation

BACKGROUND: A large number of preclinical studies have shown that local anesthetics have a direct inhibitory effect on tumor biological activities, including cell survival, proliferation, migration, and invasion. There are few studies on the role of local anesthetics in cancer stem cells. This study...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Fan, Xiaoqing, Yang, Haoran, Zhao, Chenggang, Hu, Lizhu, Wang, Delong, Wang, Ruiting, Fang, Zhiyou, Chen, Xueran
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863430/
https://ncbi.nlm.nih.gov/pubmed/33541421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02175-2
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